Research Articles
Unlocking the Dual Nature of Stress: Molecular Mechanisms of Hormesis in Redox Signaling Pathways
This article provides a comprehensive analysis of the molecular mechanisms underpinning hormesis in redox signaling, a fundamental biological process where low-dose stressors elicit beneficial adaptations.
Real-Time Hydrogen Peroxide Monitoring in Live Cells: A MoS2-RGO FET Biosensor Protocol
This article provides a comprehensive guide for researchers and drug development scientists on the implementation of Molybdenum Disulfide-Reduced Graphene Oxide (MoS2-RGO) Field-Effect Transistor (FET) biosensors for the real-time, non-invasive detection...
Mitochondrial Redox Signaling and ETC Dynamics: From Fundamental Mechanisms to Therapeutic Targeting in Disease
This comprehensive review for researchers and drug development professionals explores the intricate relationship between mitochondrial electron transport chain (ETC) function and redox signaling.
Mastering MST for MsrB1: A Complete Guide to Binding Assays for Drug Discovery
This comprehensive guide details the application of Microscale Thermophoresis (MST) for characterizing the binding interactions of Methionine Sulfoxide Reductase B1 (MsrB1), a key enzyme in oxidative stress regulation and a...
From Disulfides to Sulfenic Acids: A Comprehensive Guide to Cysteine Oxidation State Analysis in Protein Research
Cysteine redox modifications are critical regulators of protein function, signaling, and disease.
Redox Signaling Mechanisms: How Cysteine Modification Controls Cellular Function and Disease Pathways
This article provides a comprehensive analysis of redox signaling mediated by post-translational cysteine modification, tailored for researchers and drug development professionals.
Mapping H₂O₂ Flux: Cutting-Edge Techniques for Measuring Subcellular Hydrogen Peroxide Gradients in Biomedicine
Hydrogen peroxide (H₂O₂) functions as a key redox signaling molecule, with its biological impact dictated by precise concentration, localization, and dynamics within subcellular compartments.
Hormesis in Redox Biology: Methods to Measure the Biphasic Dose-Response for Research & Drug Discovery
This comprehensive guide provides researchers and drug development professionals with a practical framework for measuring and interpreting hormetic responses in redox biology.
Decoding Electron Transfer in Engineered Proteins: A Marcus Theory Guide for Researchers & Drug Developers
This article explores the critical application of Marcus theory to the design and analysis of electron transfer in engineered proteins, targeting researchers and drug development professionals.
Quantifying Inhibition: A Practical Guide to MicroScale Thermophoresis (MST) Binding Assays for MsrB1 Drug Discovery
This comprehensive guide details the application of MicroScale Thermophoresis (MST) for determining the binding affinity of inhibitors targeting Methionine Sulfoxide Reductase B1 (MsrB1), a promising therapeutic target.